Research Article
Probiotics (Bifidobacterium longum) Increase Bone Mass Density and Upregulate Sparc and Bmp-2 Genes in Rats with Bone Loss Resulting from Ovariectomy
Figure 5
Effect of B. longum on Bmp-2 gene expression. Ten-week-old female Sprague-Dawley rats were supplemented with 1 mL B. longum (108–109 CFU) once a day for 16 weeks, starting 2 weeks after surgery, while the sham and OVX groups received 1 mL of demineralized water. At the end of the study, Bmp-2 expression was quantified by RT-PCR. Values represent the mean ± SEM ( in each group). abcValues with different letters are significantly different at based on one-way ANOVA, followed by Tukey’s post hoc test.