| | Results |
Number of studies |
Sample size
FNAC/FNNAC | Overall effect size | 95% CI | value | Heterogeneity | | |
| | Unsuitable for diagnosis | 12 [8, 10–14, 20, 23–27] | 1912/1912 | OR = 1.09 | (0.91, 1.30) | 0.36 | 40% | 0.07 | | Diagnostically superior | 11 [8, 10–14, 23–27] | 1844/1844 | OR = 0.81 | (0.60, 1.09) | 0.16 | 73% | <0.0001 | | Background blood or clot | 5 [8, 10, 13, 24, 28] | 986/986 | MD = −0.41 | (−0.84, 0.02) | 0.06 | 98% | <0.0001 | | Degree of cellular trauma | 5 [8, 10, 13, 24, 28] | 986/986 | MD = 0.06 | (−0.14, 0.26) | 0.56 | 90% | <0.00001 | | Amount of cellular material | 5 [8, 10, 13, 24, 28] | 986/986 | MD = −0.11 | (−0.35, 0.13) | 0.35 | 92% | <0.00001 | | Degree of cellular degeneration | 5 [8, 10, 13, 24, 28] | 986/986 | MD = 0.05 | (−0.10, 0.21) | 0.51 | 81% | 0.0003 | | Retention of appropriate architecture | 5 [8, 10, 13, 24, 28] | 986/986 | MD = −0.27 | (−0.69, 0.15) | 0.21 | 97% | <0.00001 | | Total score of five parameters | 5 [8, 10, 13, 14, 24] | 1172/1172 | MD = −0.36 | (−1.03, 0.30) | 0.29 | 90% | <0.00001 | | Accuracy | 5 [10, 15, 19–21] | 182/192 | OR = 0.96 | (0.56, 1.65) | 0.89 | 12% | 0.34 | | Sensitivity | 4 [10, 15, 19, 21] | 146/154 | OR = 1.35 | (0.35, 5.19) | 0.66 | 0% | 0.74 | | Specificity | 4 [10, 15, 19, 21] | 146/154 | OR = 1.13 | (0.56, 2.29) | 0.73 | 20% | 0.26 | | Negative predictive value (NPV) | 4 [10, 15, 19, 21] | 146/154 | OR = 1.20 | (0.35, 4.11) | 0.78 | 0% | 0.78 | | Positive predictive value (PPV) | 4 [10, 15, 19, 21] | 146/154 | OR = 1.17 | (0.50, 2.76) | 0.71 | 0% | 0.46 |
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