Review Article

The Review on Properties of Aloe Vera in Healing of Cutaneous Wounds

Table 1

Growth factors in wound healing [7].

Growth factorSourceWound healing related functions

PDGFPlatelets, macrophages, endothelial cells, injured cellsChemotaxis, fibroblast proliferation, collagenase production

TGF-βMacrophages, platelets, neutrophils, lymphocytes, fibroblasts, epithelial and endothelial cells, injured cellsChemotaxis, fibroblast proliferation, collagen metabolism

EGFMacrophages, platelets, plasma, epithelial cellsEpithelial cells proliferation, granulation tissue formation

TGF-αActivated macrophages, platelets, injured cells, epithelial cellsEpithelial cells proliferation, granulation tissue formation

KGFFibroblastsEndothelial cells proliferation

IL-1MacrophagesFibroblast proliferation

FGFMacrophages, fibroblasts, pituitary, endothelial cellsFibroblast proliferation, matrix deposition, wound contraction angiogenesis

TNF-αMacrophages, T lymphocytesFibroblast proliferation

IGF-1Plasma, liver, fibroblastsSynthesis of sulfated proteoglycans and collagen, fibroblast proliferation

IFNsLymphocyte, fibroblastsInhibition of fibroblast proliferation and collagen synthesis