Research Article

The Influence of Tea Tree Oil (Melaleuca alternifolia) on Fluconazole Activity against Fluconazole-Resistant Candida albicans Strains

Table 4

MIC and MFC values of fluconazole, TTO, terpinen-4-ol, and fluconazole with TTO or terpinen-4-ol, for fluconazole-resistant Candida albicans strains.

ReagentsC. albicans
ATCC 10231
C. albicans clinical strains ( = 32)
MIC MFCMICMFC
RangeAverageRangeAverage

Fluconazole μg/mL256.0256.064.0–256.0244.0 ± 47.22213.33–256.0254.48 ± 7.44
TTO % v/v0.1250.250.06–0.50.19 ± 0.090.125–0.50.37 ± 0.13
Fluconazole μg/mL with sublethal dose of TTO256.0256.00.125–256.038.46 ± 84.350.17–256.066.62 ± 96.16
Terpinen-4-ol % v/v0.060.1250.06–0.250.11 ± 0.090.125–0.50.22 ± 0.19
Fluconazole μg/mL with sublethal dose of terpinen-4-ol0.1250.1250.125-0.1250.125 ± 0.00.125–1.00.38 ± 0.42