Tetramethylpyrazine Enhances Vascularization and Prevents Osteonecrosis in Steroid-Treated Rats

Figure 2

Tetramethylpyrazine (TMP) improves hyperlipidemia in steroid-induced ONFH rats. The steroid hormone administration (model group) induced marked hyperlipidemia, such as significantly elevated TG (a), TC (b), LDL (c), ApoA1 (e), and ApoB (f) levels, but significantly decreased HDL levels (d). More interestingly, doses of 20~40 mg/kg TMP could significantly reduce hyperlipidemia by decreasing TG (a), TC (b), LDL (c), ApoA1 (e), and ApoB (f) levels and increasing HDL levels (d). Data are represented as the mean ± S.D. ( for control; for model; for TMP 20 mg/kg, TMP 40 mg/kg, resp.). ^# and ^##, respectively, compared with the control group. and , respectively, compared with the model group.

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