Morphine Promotes Tumor Angiogenesis and Increases Breast Cancer Progression

Figure 2

Morphine promotes the tumor growth in TBNC mouse model. (a) Morphine promotes tumor growth in breast tumor xenograft model. Breast tumor growth in mice treated with vehicle (•) and morphine (▪). Tumor volumes increased after 28 days of morphine treatment until 35 days () as compared with control (vehicle-treated). Each point represents the mean of five separate experiments. (b-c) Measurements of fluorescence per second depicting microvessel tumor (FITC-DEXTRANE) using MacroFluo images showed that morphine enhances the angiogenesis in tumor of mice (b) with respect to controls (c).

(a)

(b)

(c)