Cell Microenvironment Engineering and Monitoring for Tissue Engineering and Regenerative Medicine: The Recent Advances
Figure 3
Manipulating the cell microenvironment in 3D via encapsulation within hydrogels. Encapsulation of prostate cancer cells within PEG hydrogels resulted in more pronounced cell-cell contacts as evidenced by E-cadherin staining (a) and also formation of a necrotic core within the cell aggregates as shown by pimonidazole staining (b). All scale bars are 75 μm for (a) and 100 μm for (b). Reproduced from [9].
