Review Article

Cell Microenvironment Engineering and Monitoring for Tissue Engineering and Regenerative Medicine: The Recent Advances

Figure 1

The effect of microlevel mechanical confinement on the division of HeLa cells. (a) and (b) show the macroscopic structure of the microfluidic system and the cross-section of PDMS posts. By the application of pressure on the posts, cells can be confined within the area between the posts (the distance between the posts is 40 μm) (c). The confinement caused significant changes in the behavior of the cells during mitosis, such as delays in mitosis, and led to daughter cells of different sizes and multidaughter cells following mitosis. Reproduced from [4].
921905.fig.001a
(a)
921905.fig.001b
(b)
921905.fig.001c
(c)