Assessment of Cardiac Sarcoidosis with Advanced Imaging Modalities

Table 1

Sensitivity and specificity of ¹⁸F-FDG PET in the diagnosis of CS.

Authors	Year	Subjects studied	JMHW guidelines	No. of patients ()	Fasting time (h)	Sensitivity (%)	Specificity (%)	Comments
Yamagishi et al. [38]	2003	With CS	1993	17	>5	82	NA	First systemic research
Okumura et al. [34]	2004	With sarcoidosis	1993	22	>12	100	91	PET is more sensitive; than ^67Ga scintigraphy
Ishimaru et al. [35]	2005	With sarcoidosis	1993	32	>6	100	82	Pre-administered heparin
Ohira et al. [32]	2008	With suspected CS	1993	21	>12	88	39	Comparing; ^18F-FDG PET and MRI
Langah et al. [36]	2009	With suspected CS	1993	76	>18	85	90	PET CT with prolonged fasting >18 h
Tahara et al. [37]	2010	With suspected CS	2006	24	>12	100	46→97	Analysis using the COV improved specificity
Manabe et al. [39]	2013	With suspected CS	1993	67	>6	96	62	^18F-FDG uptake was related to ECG abnormalities
McArdle et al. [40]	2013	With suspected CS	2006	134	>12	100	83	With a high-fat, low-carbohydrate diet on the day before PET
Blankstein et al. [33]	2013	With suspected CS	1993	118	>3	71	45	With a high-fat, high protein, low-carbohydrate diet

CS: cardiac sarcoidosis, ¹⁸F-FDG PET: ¹⁸F-fluorodeoxyglucose positron emission tomography, JMHW: Japanese Ministry of Health and Welfare, COV: coefficient of variation.