Intensive Insulin Therapy for Septic Patients: A Meta-Analysis of Randomized Controlled Trials

Table 2

Risk of bias in included randomized controlled trials.

Study	Random sequence generation	Allocation concealment	Blinding of participants and personnel	Blinding of outcome assessment	Incomplete outcome data	Selective reporting	Other sources of bias
Cappi 2012 [14]	Low risk	Low risk	High risk	Low risk	Low risk	Low risk	Low risk
COIITSS 2010 (France) [16]	Low risk	Low risk	High risk	Low risk	Low risk	Low risk	High risk^a
Savioli 2009 [12]	Low risk	Unclear	High risk	Low risk	Low risk	Low risk	Low risk
Iapichino 2008 [11]	Low risk	Unclear	High risk	High risk	Low risk	Unclear	Low risk
Brunkhorst 2008 [10]	Low risk	Low risk	High risk	High risk	Low risk	Low risk	High risk^a,b
Ellger 2008 [25]	Low risk	Low risk	High risk	Low risk	Low risk	Low risk	Low risk
Yu 2005 [13]	Unclear	Unclear	High risk	Low risk	Low risk	High risk	Low risk
Dong 2009 [27]	Unclear	Unclear	High risk	High risk	Low risk	Unclear	Low risk
NICE-SUGAR 2009 (Australia and New Zealand—Canada) [17]	Low risk	Low risk	High risk	Low risk	Low risk	Low risk	High risk^c
Arabi 2008 [24]	Low risk	Low risk	High risk	Low risk	Low risk	Low risk	High risk^d
Zhang 2008 [26]	Unclear	Unclear	High risk	Low risk	Low risk	Unclear	Low risk
Jin 2009* [23]	NA	NA	NA	NA	NA	NA	NA

∗Abstract only.
NA: not available from article or author.
aThe two treatment groups differ in the use of medications other than insulin.
bIntensive insulin therapy was terminated early because of increasing hypoglycemic events.
cInclusion used subjective criteria.
dIt had a different baseline.