Survey on Knowledge, Attitudes, and Training Needs of Italian Residents on Genetic Tests for Hereditary Breast and Colorectal Cancer
Table 3
Sociodemographic and professional characteristics associated with knowledge on genetic testing for breast cancer (BRCA1/BRCA2 mutations) and colorectal cancer (APC mutations).
Breast cancer
Colorectal cancer
OR
95% CI
OR adj*
95% CI
OR
95% CI
OR adj
95% CI
Gender
Female
1.00
1.00
1.00
1.00
Male
0.53
0.34–0.83
0.55
0.35–0.87
1.24
0.74–2.06
1.36
0.80–2.31
Age
<28
1.00
1.00
1.00
1.00
28-29
0.72
0.39–1.32
0.66
0.35–1.24
0.78
0.42–1.43
0.74
0.39–1.41
30-31
0.70
0.36–1.37
0.62
0.31–1.26
0.32
0.14–0.73
0.25
0.10–0.61
≥32
0.71
0.33–1.54
0.68
0.30–1.56
0.39
0.15–0.99
0.33
0.12–0.92
Personal or family history of breast or colon cancer
No
1.00
1.00
1.00
1.00
Yes
1.40
0.77–2.57
1.21
0.65–2.25
0.98
0.52–1.86
0.91
0.47–1.77
Professional area~
Medicine
1.00
1.00
1.00
1.00
Surgery
0.60
0.31–1.17
0.80
0.39–1.64
1.10
0.50–2.40
1.24
0.55–2.80
Others
1.16
0.72–1.87
1.20
0.74–1.96
0.90
0.52–1.55
0.88
0.50–1.55
Clinical activity
No
1.00
1.00
1.00
1.00
Yes
0.94
0.59–1.50
0.97
0.60–1.57
0.93
0.55–1.58
1.02
0.59–1.76
Exposure to cancer genetic testing during graduate training
No
1.00
1.00
1.00
1.00
Yes
1.73
1.06–2.82
1.72
1.05–2.82
2.01
1.05–3.84
2.08
1.07–4.03
Postgraduate training courses in epidemiology and EBM
No
1.00
1.00
1.00
1.00
Yes
0.90
0.50–1.61
0.88
048–1.60
1.85
1.01–3.45
1.95
1.03–3.69
Patient request of cancer genetic tests in the previous yeari
No
1.00
1.00
1.00
1.00
Yes
2.15
1.05–4.38
1.84
0.89–3.83
0.90
0.42–1.92
0.84
0.38–1.84
Hours per week dedicated to continuing medical education
<1
1.00
1.00
1.00
1.00
1–5
1.45
0.76–2.75
1.39
0.71–2.73
1.31
0.57–3.00
0.98
0.41–2.30
6–10
2.03
0.93–4.41
2.11
0.93–4.77
1.64
0.65–4.14
1.25
0.48–3.29
>10
1.73
0.61–4.96
1.84
0.62–5.43
1.32
0.38–4.56
0.74
0.19–2.91
Promotional material about breast or colon cancer received in the previous year
No
1.00
1.00
1.00
1.00
Yes
1.29
0.65–2.56
1.12
0.56–2.25
0.67
0.25–1.82
0.41
0.14–1.25
OR: odds ratio; CI: confidence interval; EBM: evidence based medicine.
*OR adjusted by professional area, exposure to cancer genetic testing during graduate training. OR adjusted by gender, postgraduate training courses about epidemiology and EBM. ~List of specializations according to each area is available in Supplementary file S1.
iIncluded physicians with clinical activity.
