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Symbol
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Access no.
| Fold change |
Description
| 24 h | 48 h | 72 h | 400 µM | 600 µM | 800 µM | 400 µM | 600 µM | 800 µM | 400 µM | 600 µM | 800 µM |
| Cell cycle checkpoint | | | | | | | | | | | | G1/S DNA damage checkpoint | | | | | | | | | | | | CDC25A | NM_001789 | — | — | −2,090 | — | — | — | −2,408 | — | — | Cell division cycle 25 homolog A (S. pombe) | CDC25B | NM_021873 | — | — | — | — | — | — | −2,980 | −2,686 | −2,415 | Cell division cycle 25 homolog B (S. pombe) | CDC25C | NM_001790 | — | — | −2,155 | −2,306 | — | −2,050 | −3,588 | — | — | Cell division cycle 25 homolog C (S. pombe) | p53-dependent G1/S DNA Damage checkpoint | | | | | | | | | | | | TP53 | NM_000546 | — | 2,447 | 2,503 | — | — | — | 3,150 | — | 3,650 | Tumor protein p53 | CDKN1A | NM_078467 | — | 3,074 | 2,789 | — | — | — | — | −2,254 | −2,203 | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | GADD45A | NM_001924 | — | — | — | — | — | — | 4,194 | 2,493 | 2,047 | Growth arrest and DNA-damage-inducible, alpha | GADD45B | NM_015675 | 2,352 | — | 2,191 | 2,864 | 2,792 | 2,899 | 4,016 | 5,479 | 5,200 | Growth arrest and DNA-damage-inducible, beta | GADD45G | NM_006705 | — | 2,208 | 2,661 | | 2,379 | 4,796 | 5,081 | 14,121
| 22,532 | Growth arrest and DNA-damage-inducible, gamma | TP53INP1 | NM_033285 | 2,033 | 3,475 | 5,494 | 3,071 | — | — | — | — | — |
Tumor protein 53 inducible nuclear protein 1
| TP53I3 | NM_004881 | — | — | — | — | — | 2,214 | — | — | 2,406 |
Tumor protein p53 inducible protein 3
| MDM2 | NM_002392 | 2,534 | — | 2,868 | 3,019 | 4,111 | 3,165 | — | 4,369 | — | Mdm2 p53 binding protein homolog (mouse) | Cell cycle mitotic | | | | | | | | | | | | G1/S transition | | | | | | | | | | | | CCNE1 | NM_001238 | — | — | — | — | −2,328 | −2,652 | −3,523 | — | — |
Cyclin E1
| CDKN1A | NM_078467 | — | 3,074 | 2,789 | — | — | — | — | −2,254 | −2,203 |
Cyclin-dependent kinase inhibitor 1A (p21, Cip1)
| CDKN1B | NM_004064 | — | — | — | — | — | 2,477 | 2,432 | 3,367 | 4,938 | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | CDC2 | NM_001786 | — | — | −2,540 | −3,260 | −2,250 | −3,940 | −5,820 | −2,730 | −3,420 | Cell division cell cycle 2 | RB1 | NM_000321 | — | — | — | — | — | — | — | 2,872 | 2,473 | Retinoblastoma 1 | DNA replication / E2F mediated regulation of DNA replication | | | | | | | | | | | | E2F1 | NM_005225 | — | — | — | −2,283 | −3,073 | −2,740 | −7,552 | −4,090 | −3,215 | E2F transcription factor 1 | CDT1 | NM_030928 | — | — | — | −2,571 | −2,727 | −2,332 | −5,931 | −3,269 | −2,202 | Chromatin licensing and DNA replication factor 1 | PCNA | NM_002592 | — | — | — | −2,073 | −2,320 | −3,481 | −3,900 | −5,797 | −8,575 | Proliferating cell nuclear antigen | DHFR | NM_000791 | — | — | — | — | −2,466 | −2,157 | −2,376 | −4,963 | −7,712 |
Dihydrofolate reductase | TYMS | NM_001071 | — | — | — | −2,088 | −3,595 | −4,872 | −8,869 | −9,976 | −11,282 |
Thymidylate synthase | POLA2 | NM_002689 | — | — | — | — | — | — | −3,763 | −4,911 | −6,198 | DNA polymerase alpha2 | POLA1 | NM_016937 | — | — | — | — | — | — | −2,098 | — | −2,014 | DNA polymerase alpha 1 | POLD2 | NM_006230 | — | — | — | — | −2,794 | −2,403 | −2,611 | −3,001 | −2,114 | DNA polymerase delta 2 | POLD3 | NM_006591 | — | — | −2,244 | — | −2,135 | — | −2,992 | — | — | DNA polymerase delta 3 | POLE2 | NM_002692 | — | — | −2,033 | −3,289 | −6,780 | −6,793 | −8,488 | −10,860 | −11,678 | DNA polymerase epsilon 2 | POLE4 | NM_019896 | — | — | — | — | — | −2,154 | — | −2,118 | — | DNA polymerase epsilon 4 | ORC1L | NM_004153 | — | — | — | −2,914 | −2,588 | −2,538 | −5,605 | −2,337 | — | Origin recognition complex, subunit 1-like (yeast) | RRM2 | NM_001034 | — | — | — | −2,467 | −2,485 | −4,266 | −6,902 | −4,767 | −4,299 | Ribonucleotide reductase M2 subunit | Regulation of DNA replication | | | | | | | | | | | | ORC2L | NM_006190 | — | — | — | — | — | — | 2,288 | 2,727 | 2,570 | Origin recognition complex, subunit 2-like (yeast) | ORC4L | NM_002552 | — | — | — | — | — | 3,216 | 2,171 | — | — | Origin recognition complex, subunit 4-like (yeast) | ORC5L | NM_181747 | — | — | — | — | — | — | 2,209 | 2,902 | 2,765 | Origin recognition complex, subunit 5-like (yeast) | ORC6L | NM_014321 | — | — | — | −2,348 | — | — | — | −2,415 | — | Origin recognition complex, subunit 6-like (yeast) | MCM2 | NM_004526 | — | — | — | −2,664 | −3,036 | −2,943 | −6,176 | −4,620 | −3,494 | Minichromosome maintenance complex component 2 | MCM3 | NM_002388 | — | — | — | −2,105 | −3,104 | −3,458 | −4,038 | −3,948 | −4,356 | Minichromosome maintenance complex component 3 | MCM4 | NM_005914 | — | — | — | −2,267 | −2,266 | −2,464 | −3,923 | −5,040 | −7,344 | Minichromosome maintenance complex component 4 | MCM5 | NM_006739 | — | — | — | −2,360 | −3,103 | −3,392 | −7,464 | −4,613 | −3,677 | Minichromosome maintenance complex component 5 | MCM6 | NM_005915 | — | — | — | −2,320 | −2,056 | — | — | — | — | Minichromosome maintenance complex component 6 | MCM7 | NM_182776 | — | — | −2,175 | −2,563 | — | — | −2,617 | −2,024 | −2,345 | Minichromosome maintenance complex component 7 | TK1 | NM_003258 | — | — | −2,384 | −3,839 | −5,606 | −7,557 | −24,478 | −7,567 | −5,991 | Thymidine kinase 1, soluble | FEN1 | NM_004111 | — | — | −2,008 | −2,268 | — | −2,110 | −4,470 | −3,294 | −2,587 | Flap structure-specific endonuclease 1 | LIG1 | NM_000234 | — | — | — | −2,626 | −3,753 | −3,867 | −8,964 | −6,958 | −5,640 | DNA Ligase 1 | Apoptosis | | | | | | | | | | | | CASP3 | NM_004346 | — | — | — | — | — | 2,097 | — | 2,239 | 2,112 | Caspase-3 | CASP7 | NM_033339 | — | — | — | — | 2,124 | 2,097 | 2,050 | 2,335 | 2,393 | Caspase-7 | CASP8 | NM_033356 | — | — | — | — | — | — | 3,686 | 2,420 | 3,056 | Caspase-8 | CASP9 | NM_001229 | — | — | — | — | — | — | — | 2,221 | 2,257 | Caspase-9 | CASP10 | NM_032977 | — | — | — | — | — | — | — | 3,617 | 4,514 | Caspase-10 | DFFA | NM_213566 | — | — | — | — | — | — | — | — | 2,034 | DNA fragmentation factor, 45kDa, alpha polypeptide | DFFB | NM_001004285 | — | — | — | — | — | — | 4,015 | 2,121 | 4,583 | DNA fragmentation factor, 40 kD, beta polypeptide (caspase-activated DNase) |
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