Review Article

Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes

Table 1

The age-related pathologies in Sod1−/− mice.

BrainAcceleration of Alzheimer’s disease[11, 12]
EyeMacular degeneration[13, 14]
Cataract[15]
Dry eye[16, 17]
EarCochlear hair cell loss[18]
Hearing loss[19]
BloodHemolytic anemia[20]
BoneOsteopenia[21, 22]
SkinSkin atrophy[23, 24]
MuscleSkeletal muscle atrophy[25]
PancreasGlucose intolerance[26, 27]
LiverHepatocellular carcinoma[9]
Fatty deposits[28]
OvaryInfertility[29, 30]
Luteal degeneration[31]