Alteration of ROS Homeostasis and Decreased Lifespan in S. cerevisiae Elicited by Deletion of the Mitochondrial Translocator FLX1
Figure 6
A possible correlation between mitochondrial FAD homeostasis and chronological lifespan. The scheme summarizes results from studies described in this and other papers [17, 19, 22, 26, 35, 36, 40, 50, 53]. Mch5p, plasma membrane Rf transporter; Rib1-5/7p, enzymes involved in Rf de novo biosynthesis; , mitochondrial riboflavin transporter; Fmn1p, riboflavin kinase; mtFADS, mitochondrial FAD synthase; Flx1p, mitochondrial FAD exporter; I, FAD pyrophosphatase; Sdh1p, succinate dehydrogenase flavoprotein subunit; Sdh5p, protein required for Sdh1p flavinylation; Sdh2/3/4p, other subunits of succinate dehydrogenase complex; Tmp62p/Sdh6p, factors required for SDH complex assembly; TCA cycle, tricarboxylic acid cycle; TOM complex/TIM complex, proteins involved in mitochondrial protein import; Dic1p, mitochondrial dicarboxylic acid carrier; PDH, prolyl hydroxylase; JmjC, JmjC-domain-containing demethylases, Rox1p, heme-dependent repressor of hypoxic genes; Msn2/4p, transcriptional factors activated in stress conditions.
