Research Article

Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E2 and Nitric Oxide during Experimental Murine Paracoccidioidomycosis

Table 1

Total lipid content and fatty acid composition of the experimental diets.

CompositionControl dietPerilla meal-supplemented diet
Means ± SDMeans ± SD

Total lipids (%)6.5 ± 1.156.8 ± 1.4

Fatty acid
(mg/g total lipids)
 16:0127.8a ± 0.23101.8b ± 1.67
 17:00.7 ± 0.02nd
 18:026.5a ± 0.1216.9b ± 0.26
 18:1n-9211.5a ± 0.69152.4b ± 2.05
 18:1n-79.7 ± 0.039.5 ± 0.11
 18:2n-6 (LA)422.7a ± 1.75265.2b ± 1.38
 18:3n-60.2 ± 0.29nd
 18:3n-3 (LNA)34.5a ± 0.08310.7b ± 1.80
 20:02.9a ± 0.011.7b ± 0.01
 20:1n-93.4a ± 0.022.5b ± 0.07

MUFA222.7a ± 0.36136.1b ± 1.06
SFA157.9a ± 0.21120.3b ± 0.95
PUFA464.0a ± 0.87577.3b ± 0.97
n-6422.9a ± 1.75266.6b ± 0.99
n-334.5a ± 0.08310.7b ± 1.80
PUFA/SFA2.9 ± 0.058.3 ± 0.02
n-6/n-312.2a ± 0.030.9b ± 0.05

PUFA: polyunsaturated fatty acid, MUFA: monounsaturated fatty acid, SFA: saturated fatty acid, n-6: omega-6 fatty acid, and n-3: omega-3 fatty acid. Results expressed as mean ± standard deviation for analysis in nine replicates. . Means followed by different letters on the same line are significantly different ( ) by Tukey’s test and -test. Control diet versus perilla meal-enriched diets. nd: not detected.