Antiosteoclastic Activity of Milk Thistle Extract after Ovariectomy to Suppress Estrogen Deficiency-Induced Osteoporosis

Table 2

Osteogenic activity of milk thistle extract (MTE) and silibinin in ovariectomized (OVX) mice.

	Sham control	OVX	OVX-MTE	OVX-silibinin
BMD	74.4 ± 2.0^a	61.0 ± 0.8^c	72.5 ± 1.9^a	67.4 ± 0.4^b
BMC	17.6 ± 0.4^a	15.1 ± 0.2^c	17.2 ± 0.7^a	16.4 ± 0.2^b
Bone area	0.237 ± 0.003	0.250 ± 0.004	0.238 ± 0.006	0.244 ± 0.004

C57BL/6 female mice (11 weeks of age, 20–25 g) were ovariectomized and orally supplemented with 10 mg/kg MTE and silibinin daily for 8 weeks. Areal bone mineral density (BMD, mg/cm²), bone mineral content (BMC, mg), and bone area (cm²) were measured in femur bones by using a PIXImus mouse densitometer. Values are means ± SEM of 9 mice. Respective values in the same row not sharing the same superscript differ, 𝑃<0.05.