Pharmacodynamic Analysis of Magnetic Resonance Imaging-Monitored Focused Ultrasound-Induced Blood-Brain Barrier Opening for Drug Delivery to Brain Tumors

Figure 8

(a) Instantaneous R₁ values of the normal animals, 10-day and 17-day tumor animals at MRI acquisition time slots I, II, and III. (b) Ratio of instantaneous R₁ to the value in time slot I. (c) Corresponding R₁ AUC of (a). (d) Ratio of R₁ AUC to the value in time slot I.

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(b)

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(d)