Pharmacodynamic Analysis of Magnetic Resonance Imaging-Monitored Focused Ultrasound-Induced Blood-Brain Barrier Opening for Drug Delivery to Brain Tumors
Figure 7
(a) Correlation between quantified Evans blue concentration and R1-estimated Gd-DTPA concentration in normal (red circle) and tumor (blue triangle) brains. Left arrow: contralateral side and right arrow: with FUS (red circle); normal tumor (blue triangle). (b) Evans blue after FUS exposure in the normal contralateral region, normal FUS targeting region, 10-day tumor region after FUS, and 17-day tumor region after FUS. (c) Correlation of the ratios of FUS: contralateral concentrations of Evans blue and Gd-DTPA in normal and tumor-bearing brains.
