Pharmacodynamic Analysis of Magnetic Resonance Imaging-Monitored Focused Ultrasound-Induced Blood-Brain Barrier Opening for Drug Delivery to Brain Tumors

Figure 6

(a) Instantaneous R₁ measured immediately or 80 minutes after FUS exposure in normal animals, 10-day and 17-day tumor animals. (b) Ratio of instantaneous R₁ values, immediately and 80 min after FUS. (c) Corresponding R₁ AUC of (a). Images were acquired in time slot II.

(a)

(b)

(c)