Pharmacodynamic Analysis of Magnetic Resonance Imaging-Monitored Focused Ultrasound-Induced Blood-Brain Barrier Opening for Drug Delivery to Brain Tumors
Figure 3
(a) T1 image and corresponding R1 map for the in vitro Gd-DTPA phantom at increasing concentrations (1 and 2: water; 3: 0.12 μM; 4: 0.24 μM; 5: 0.49 μM; 6: 0.97 μM; 7: 1.96 μM; 8: 3.9 μM). (b) Dependence of R1 on Gd-DTPA concentration; relaxivity was estimated as about 3.2936 s−1 mM−1. (c) Calibration curve of spectrophotometrically determined EB concentration. EB concentrations ranging from 0 to 0.8 μg were tested, resulting in O.D. readings of 0.035 to 0.19 at 620 nm.
