BioMed Research International

Review Article

Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma

Table 1

Human integrin subunits and their ligands.
IntegrinLigand Type of receptors
α5β1FibronectinRGD receptors
α8β1Fibronectin/vitronectin/nephronectin
αvβ1Fibronectin/vitronectin
αvβ3Vitronectin/fibronectin/fibrinogen
αvβ5Vitronectin
αvβ6Fibronectin
αvβ8Vitronectin
αIIbβ3Fibrinogen/fibronectin
α1β1Collagen I/collagen IV/collagen IXCollagen receptor
α2β1Collagen I/collagen IV/collagen IX
α10β1Collagen II/collagen IV/collagen VI/collagen IX
α11β1Collagen I/collagen IV/collagen IX
α3β1Laminin-511/laminin-332/laminin-211Laminin receptor
α6β1Laminin-511/laminin-332/laminin-111/laminin-411
α6β4Laminin-511/laminin-332
α7β1Laminin-511/laminin-211/laminin-111/laminin-411
α4β1Fibronectin/VCAM-1Leukocyte-specific receptors
α4β7
α9β1		MadCAM-1/fibronectin/VCAM-1
tenascin-C/VEGF-C/VEGF-D
αDβ2ICAM-3/VCAM-1
αLβ2ICAM-1/ICAM-2/ICAM-3/ICAM-5
αMβ2iC3b/fibronectin + more
αXβ2iC3b/fibronectin + more
αEβ7E-cadherin
RGD: arginine-glycine-aspartate, MadCAM: mucosal addressin cell adhesion molecule, ICAM: intercellular adhesion molecule, VCAM: vascular celladhesion molecule, and VEGF: vascular endothelial growth factor.