Research Article

Effects of Reactive Nitrogen Scavengers on NK-Cell-Mediated Killing of K562 Cells

Table 2

The effect of RNM scavengers on NK-cell cytotoxicity of ONOO.

GroupsNO (6 h) (μmol/mL)NK (6 h) %NK (24 h) %TNF-β (24 h) pg/mLIFN-γ (24 h) pg/mLNCC (24 h)%

E + T 9 5 . 3 6 ± 6 . 4 5 9 0 . 5 7 ± 2 . 5 2 9 3 . 1 7 ± 2 . 5 7 1 9 8 . 6 4 ± 7 . 3 3 1 4 6 . 4 3 ± 6 . 4 9 6 7 . 4 7 ± 2 . 6 4
E + T + O N O O 2 6 1 . 0 3 ± 6 . 5 7 8 0 . 9 7 ± 1 . 6 8 7 1 . 8 7 ± 1 . 0 2 9 1 . 6 8 ± 6 . 0 0 58.47±70 4 3 . 4 4 ± 2 . 8 7
E + T + D H C + O N O O 2 5 5 . 3 2 ± 1 1 . 9 3 8 2 . 2 7 ± 1 . 3 8 7 3 . 6 0 ± 2 . 7 6 1 1 8 . 7 3 ± 5 . 5 6 * 7 0 . 4 0 ± 7 . 1 5 * 4 5 . 2 6 ± 3 . 3 1
E + T + TIP + O N O O 1 7 9 . 6 5 ± 7 . 0 0 * 9 0 . 0 7 ± 1 . 2 3 * 9 1 . 1 3 ± 3 . 6 7 * 1 3 1 . 0 3 ± 5 . 4 6 * 7 6 . 8 0 ± 4 . 9 1 * 6 1 . 5 8 ± 1 . 8 9 *
E + T + GSH + O N O O 1 8 5 . 6 9 ± 5 . 0 2 * 89.87+0.35* 8 8 . 0 3 ± 1 . 4 6 * 1 2 8 . 7 0 ± 4 . 5 3 * 7 5 . 1 2 ± 6 . 4 5 * 6 0 . 6 8 ± 2 . 0 7 *

𝑛 = 3 ; 2 . ONOO 200 umol/L; DHC 20 umol/L, TIP 50 umol/L, GSH 50 umol/L; T is K562 cells, E is mononuclear enriching NK cells E/T = 10/1; * 𝑃 < 0 . 0 5 , compared with E + T + O N O O .