Manipulating Protein Acetylation in Breast Cancer: A Promising Approach in Combination with Hormonal Therapies?

Table 2

Expression of HDACs in breast cancers.

Enzyme (locus)	Total studies	Increased expression in BC	Decreased expression in BC
HDAC1 (1p34)	5	1	1
HDAC2 (6q21)	7	5	2
HDAC3 (5q31)	5	1	2
HDAC4 (2q37.3)	6	1	5
HDAC5 (17q21)	5	1	4
HDAC6 (Xp11.23)	8	0	3
HDAC7 (12q13.1)	5	0	1
HDAC8 (Xq13)	5	2	1
HDAC9 (7p21.1)	6	4	2
HDAC10 (22q13.31)	8	0	1
HDAC11 (3p25.1)	6	3	1
SIRT1 (10q21.3)	9	0	3

From Oncomine database (Compendia Bioscience, Ann Arbor, MI, USA-www.oncomine.org/). Differential expression in breast cancer (BC) versus normal breast tissue was considered significant at 𝑃<.05. Bold numbers correspond to the strongest deregulations.