TY - JOUR A2 - Yoshida, Minoru AU - Linares, AurĂ©lien AU - Dalenc, Florence AU - Balaguer, Patrick AU - Boulle, Nathalie AU - Cavailles, Vincent PY - 2011 DA - 2010/12/06 TI - Manipulating Protein Acetylation in Breast Cancer: A Promising Approach in Combination with Hormonal Therapies? SP - 856985 VL - 2011 AB - Estrogens play an essential role in the normal physiology of the breast as well as in mammary tumorigenesis. Their effects are mediated by two nuclear estrogen receptors, ERα and β, which regulate transcription of specific genes by interacting with multiprotein complexes, including histone deacetylases (HDACs). During the past few years, HDACs have raised great interest as therapeutic targets in the field of cancer therapy. In breast cancer, several experimental arguments suggest that HDACs are involved at multiple levels in mammary tumorigenesis: their expression is deregulated in breast tumors; they interfere with ER signaling in intricate ways, restoring hormone sensitivity in models of estrogen resistance, and they clinically represent new potential targets for HDACs inhibitors (HDIs) in combination with hormonal therapies. In this paper, we will describe these different aspects and underline the clinical interest of HDIs in the context of breast cancer resistance to hormone therapies (HTs). SN - 2314-6133 UR - https://doi.org/10.1155/2011/856985 DO - 10.1155/2011/856985 JF - Journal of Biomedicine and Biotechnology PB - Hindawi Publishing Corporation KW - ER -