Review Article

Histone Deacetylases in Neural Stem Cells and Induced Pluripotent Stem Cells

Figure 1

HDACs in neural stem cell proliferation and neuronal differentiation. In proliferating neural stem cells (NSCs), transcription factors (TF) recruit HDACs to the promoters of their downstream target genes, to repress the expression of cell cycle inhibitors, such as p21 and pten, and neuronal-specific genes, such as NeuroD, Neurogenin 1 (Ngn1), and Math 1, to maintain NSC proliferation and self-renewal. In addition to promote NSC proliferation, HDACs also inhibit neuronal differentiation. Treatment of HDAC inhibitors leads to induced neuronal differentiation, with increased expression of p21 and pten, and neuronal-specific genes. AC stands for histone acetylation.
835968.fig.001