The Role of HDACs Inhibitors in Childhood and Adolescence Acute Leukemias

Table 1

Main HDIs evaluated as emerging drugs for acute leukemias in pediatric and adult patients.

Compound	Structure	Chemical class	Development status
Vorinostat (SAHA)		Hydroxamic acid	Phase II
Valproic Acid		Short-chain fatty acid	Phase II
Entinostat (MS-275)		Benzamide	Preclinical and Phase I only in adults
Pivaloyloxymethyl butyrate (AN-9)		Butyric acid	Preclinical
Givinostat (ITF2357)		Hydroxamic acid	Preclinical
Depsipeptide or Romidepsin (FK228)		Cyclic tetrapeptide	Phase I only in adults
Mocetinostat (MGCD0103)		Benzamide	Phase I only in adults
Panobinostat (LBH589)		Hydroxamic acid	Phase I only in adults