Molecular Imaging, Pharmacokinetics, and Dosimetry of ¹¹¹In-AMBA in Human Prostate Tumor-Bearing Mice

Table 1

Biodistribution of ¹¹¹In-AMBA after intravenous injection in PC-3 prostate tumor-bearing SCID mice.

Organ	1 h	4 h	8 h	24 h	48 h
Blood	0.95±0.09	0.50±0.06	0.42±0.02	0.19±0.03	0.09±0.02
Brain	0.06±0.01	0.05±0.01	0.05±0.00	0.02±0.00	0.03±0.00
Skin	0.99±0.22	0.60±0.16	0.55±0.02	0.36±0.02	0.28±0.02
Muscle	0.57±0.19	0.33±0.14	0.33±0.02	0.21±0.04	0.14±0.02
Bone	1.02±0.18	0.92±0.21	1.57±0.18	0.90±0.13	0.60±0.07
Heart	0.62±0.09	0.48±0.04	0.56±0.08	0.41±0.05	0.32±0.04
Lung	1.78±0.23	1.88±0.46	1.70±0.65	0.60±0.17	0.26±0.03
Adrenals	5.79±1.21	7.08±1.22	17.8±4.65	7.41±1.99	5.20±1.11
Spleen	2.80±1.49	6.90±1.87	8.90±2.34	4.41±0.58	2.19±0.51
Pancreas	6.14±0.99	12.9±2.44	54.9±2.51	15.9±1.94	9.80±2.21
Kidney	3.56±0.15	4.23±0.28	3.92±0.91	4.10±0.72	2.74±0.30
Liver	7.26±0.53	8.22±1.05	7.04±0.24	8.64±1.31	6.59±1.83
Bladder	7.63±2.94	1.75±0.75	1.07±0.12	0.64±0.06	0.46±0.10
Stomach	0.81±0.09	0.80±0.07	3.97±1.15	0.97±0.29	0.47±0.05
SI	1.67±0.22	1.56±0.17	4.42±0.61	1.48±0.27	0.74±0.10
LI	1.77±0.25	3.42±1.10	7.04±1.48	2.39±0.38	0.99±0.16
Tumor (PC-3)	2.24±0.66	1.86±0.71	3.87±0.65	1.02±0.09	0.75±0.08
Tumor/muscle	3.89	5.69	11.79	4.82	5.16

Values are expressed as % ID/g, mean ± SEM (𝑛=4-5 at each time point). SI: small intestine; LI: large intestine.