Research Article

Trypsin Isoinhibitors with Antiproliferative Activity toward Leukemia Cells from Phaseolus vulgaris cv “White Cloud Bean”

Table 2

N-terminal sequence comparison of white cloud bean trypsin inhibitors SP3SU2 and SP2SU2 with other leguminous trypsin inhibitors (Results of BLAST search).

Trypsin inhibitorAmino acid sequences

SP3SU2GSGHRHESTDEPSSSKAACCD
SP2SU2GH -HRHESTDEPSESKKACCDHCACTKKIPPQCRRDLLLL
PVTI (34–62) –HRHESTDEPSESSKACCDHCACTKSIPPQ
VUTI (80–118) –NHHDSDSSDEPSESSEPCCDSCICSKSIPPQCHHTDIRL
VMTI (32–51) –SGRHHESTDEPSESSKPCCD
PLTI (32–51) –SGHHHESTDEPSESSKPCCD

Identical corresponding residues are underlined.
VUTI: Vigna unguiculata trypsin inhibitor.
PVTI: double-headed trypsin inhibitor from Phaseolus vulgaris.
PLTI: double-headed trypsin inhibitor from Phaseolus lunatus.
VMTI: double-headed trypsin inhibitor from Vugna mungo.