Synthetic Biology: Tools to Design, Build, and Optimize Cellular Processes

Figure 2

Interaction of components illustrating synthetic biology at the three tiers. (a) Canonical signalling pathway depicting a tier three ligand-receptor binding event that induces a tier two phosphorylation cascade which subsequently alters a promoter at the first tier. (b) Canonical allosteric protein inhibition by a molecule downstream in the pathway. The inhibition binding event is a tier three interaction which results in a tier two alteration in the pathway “set point.’’ (c) Hypothetical signalling pathway in which a signal molecule alters an initiation factor at tier three which then changes the tier two protein translation set point.