|
Virus | miRNA | Target/function | Reference |
|
Human polyomaviruses | | | |
SV40 | miR-S1 | Downregulation early expression; Immunomodulating | [45] |
BKV | miR-B1 | Downregulation early expression | [46] |
JCV | miR-J1 | Downregulation early expression | [46] |
MCPyV | miR-M1 | Downregulation early expression | [47]
|
|
Human papillomavirus | not predicted | | [65] |
| not detected | | [66]
|
|
Human adenovirus | unnamed | | [61–63]
|
|
Human parvovirus | not predicted | | [65]
|
|
HSV-1 (HHV1) | miR-LAT (within exon 1) | Prevents apoptosis by targeting translation of the genes encoding TGF-β1 and SMAD3 | [67](retracted),[48, 68, 69],[70] |
| miR-LAT- ICP34.5 | | |
| miR-H1 | Repression of the expression of the viral protein ICP0, which promotes viral replication | |
| miR-H2 | Downregulation of ICP34.5, a key viral neurovirulence factor | |
| miR-H3 | Downregulation of ICP34.5, a key viral neurovirulence factor | |
| miR-H4 | | |
| miR-H5 | Downregulation of ICP4, a viral transcriptional activator | |
| miR-H6 | Reduced expression of ICP34.5, a key viral neurovirulence factor | |
|
HSV-2 (HHV2) | miR-I | | |
| miR-II | | |
| miR-III | | |
|
VZV (HHV3) | not predicted | | [65, 71]
|
|
HCMV (HHV5) | miR-UL23 | Immunomodulating | [12, 49, 65, 72–74] |
| miR-UL36-1 | | |
| miR-UL54-1 | | |
| miR-UL70-1 | | |
| miR-UL22A-1 | | |
| miR-UL112-1 | Downregulates the expression of CMV genes involved in its own replication process, for example, transactivators IE72 and IE86; UL120/121; UL114MHC class I-related chain B (MICB), a cellular ligand for the activating receptor NKG2D; downregulation of IE-1 | |
| miR-UL148D-1 | | |
| miR-US4-1 | | |
| miR-US5-1 | | |
| miR-US5-2 | | |
| miR-US24 | | |
| miR-US25-1 | | |
| miR-US25-2 | | |
| miR-US33-1 | | |
| RNAβ2.7 | Bnds components of the mitochondrial respiratory chain complex I and thus preventing apoptosis | |
|
EBV (HHV4) | miR-BART1-1 to -3 | Inhibition LMP1 expression | [24], [51, 75–79] |
| | Inhibit EBV DNA polymerase BALF5 | |
| miR-BART2 | Inhibition LMP1 expression | |
| miR-BART3 | | |
| miR-BART4 | Antiapoptotic by downregulation of PUMA | |
| miR-BART5 | | |
| miR-BART6 | Inhibition LMP1 expression | |
| miR-BART7 | | |
| miR-BART8 | | |
| miR-BART9 | | |
| miR-BART10 | | |
| miR-BART11 | | |
| miR-BART12 | | |
| miR-BART13 | | |
| miR-BART14 | Inhibition LMP1 expression | |
| miR-BART15 | Inhibition LMP1 expression | |
| miR-BART16 | | |
| miR-BART17 | | |
| miR-BART18 | | |
| miR-BART19 | | |
| miR-BART20 | Downregulation chemokine CXCL-11 | |
| miR-BHFR-1 | | |
| miR-BHFR-2 | | |
| miR-BHFR-3 | | |
|
KSHV (HHV-8) | miR-K12-1 | Downregulation of thrombospondin 1 and BACH | [51, 66, 75, 80–82] |
| miR-K12-2 | Downregulation of thrombospondin 1 | |
| miR-K12-3 | | |
| miR-K12-4 | | |
| miR-K12-5 | Downregulation of thrombospondin 1 and BACH | |
| miR-K12-6 | | |
| miR-K12-7 | | |
| miR-K12-8 | | |
| miR-K12-9 | | |
| miR-K12-10a | | |
| miR-K12-10b | Downregulation of thrombospondin 1 and BACH-1; | |
| miR-K12-11 | Identical to miR-155 | |
| miR-K12-12 | | |
Poxvirus vaccinia virus | 3 predicted | | [65]
|
|
Poxvirus variola virus | 1 predicted | | [65]
|
|
Hepatitis B virus | | | [54]
|
|
Hepatitis C virus | | | |
|
Human immunodeficiency virus | miR-H1 | | |
Type 1 (HIV-1) | miR-TAR | HDAC-1-mediated repression of viral gene expression | [83] |
| miR-TAR-5p | | [84] |
| miR-TAR-p | | |
| HAAmiRNA | Downregulation IL-15, IL-2 receptor γ chain, IRAK1, and FMRP | [56] |
| VmiRNA#1-5 | Proteins involved in, for example, signal transduction, protein synthesis, and degradation, DNA methylation | [85] |
| miR-N367 | HIV promoter interference | [86]
|
|
HIV-2 | miR-TAR2-5p | | [87] |
| miR-TAR2-3p | | |
|
HTLV-I | not detected | | [88]
|
|
Paramyxoviridae (measles virus) | 1 predicted | | [65] |
|