Review Article

Silencing Viral MicroRNA as a Novel Antiviral Therapy?

Figure 2

Schematic representation of the genomes of different human viruses and location of viral-encoded miRNAs. (A) The human polyomavirus (HPyV) BK virus, JC virus, SV40, and Merkel Cell polyomavirus encode the viral miRNAs miR-B1, miR-J1, miR-S1, and miR-M1, respectively [4547]. (B) Herpes simplex virus-1 genome with detail of the LAT locus. The numbers refer to the approximate sequence coordinates of the LAT locus. L= long, S= short, U= unique, TR= terminal repeat, IR= internal repeat. The figure is modified after [48]. (C) Genomic map of HCMV with relative position of some of the genes. The open reading frames are depicted by thick arrows, while the position of the viral miRNAs are indicated by narrow arrows. L= long, S= short, U= unique, TR= terminal repeat, IR= internal repeat. Modified after [49] and [50]. (D) Location of the miRNAs in the EBV genome. The latency genes are shown as grey boxes, while the miRNAs are indicated by vertical lines. (E) Kaposi’s sarcoma-associated herpes virus (KSHV or HHV-8). Most KSHV miRNAs are clustered between the kaposin (K12) gene and the v-FLIP (ORF71) gene, while two are located within the K12 open reading frame (ORF). Adapted from [51]. (F) The HIV-1 genome and location of the viral-encoded miRNAs. The figure is based on a compilation of the studies by [5257].
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