Day 100 Peripheral Blood Absolute Lymphocyte/Monocyte Ratio and Survival in Classical Hodgkin's Lymphoma Postautologous Peripheral Blood Hematopoietic Stem Cell Transplantation

Table 2

Baseline characteristics based on Day 100 ALC/AMC.

Characteristics	Day 100 ALC/AMC ≥ 1.3; (𝑁 = 99)	Day 100 ALC/AMC < 1.3; (𝑁 = 32)	𝑃 value
At diagnosis
Age, years, median (range)	33 (18–68)	32 (18–56)	0.8
Gender			<0.008
Male	44 (44%)	23 (72%)
Female	55 (56%)	9 (28%)
Albumin (g/dL)	4 (2–4.6)	3.9 (2.2–4.6)	<0.008
ALC × 10^9/L	1.7 (0.2–2.9)	0.5 (0.2–2.7)	<0.0001
Hemoglobin (g/dL)	12.6 (7.7–16.2)	11.1 (8.1–15.4)	0.07
Mediastinal disease			<0.004
≥10 cm	10 (10%)	4 (34%)
<10 cm	89 (90%)	21 (66%)
Stage			0.9
I	5 (5%)	1 (3%)
II	42 (43%)	14 (44%)
III	26 (26%)	9 (28%)
IV	26 (26%)	8 (25%)
Stage			0.9
Limited	46 (47%)	15 (47%)
Advanced	52 (53%)	17 (53%)
WBC × 10^9/L	8.0 (1.4–22.2)	12.1 (2.3–20.1)	<0.0003
IPS risk factors
Age, years			0.9
≤45	82 (83%)	27 (84%)
>45	17 (17%)	5 (16%)
Albumin (g/dL); (𝑁 = 127)			<0.002
≥4	68 (71%)	12 (39%)
<4	28 (29%)	19 (61%)
ALC × 10^9/L			<0.0001
≥0.6	92 (93%)	14 (44%)
<0.6	7 (7%)	18 (56%)
Hemoglobin (g/dL)			0.06
>10.5	81 (82%)	21 (66%)
≤10.5	18 (18%)	11 (34%)
Male	44 (44%)	23 (72%)	<0.008
Stage 4	26 (26%)	8 (25%)	0.9
WBC × 10^9/L			<0.001
>15	9 (9%)	11 (34%)
≤15	90 (91%)	21 (66%)
IPS score			<0.01
0	26 (26%)	4 (13%)
1	33 (34%)	8 (25%)
2	21 (21%)	6 (18%)
3	10 (10%)	3 (9%)
4	6 (6%)	4 (13%)
5	3 (3%)	4 (13%)
6	0 (0%)	3 (9%)
IPS index			<0.009
≥3	19 (19%)	14 (44%)
<3	80 (81%)	18 (56%)
At transplant
Infused CD34+ stem cells × 10^6/kg	5.3 (2.6–15.8)	4.5 (2.1–13.2)	0.1
Pretransplant response			0.06
CR	27 (27%)	3 (9%)
PR	72 (72%)	29 (91%)
ALC × 10^9/L	0.78 (0.1–3.67)	0.39 (0.18–3.19)	<0.0001
ALC × 10^9/L			<0.0001
≥0.5	80 (81%)	10 (31%)
<0.5	19 (19%)	22 (69%)
At day 100 post-APBHSCT
Age, years	36 (18–66)	34.5 (19–58)	0.9
Hemoglobin (g/dL)	12.1 (8.5–16.7)	11.4 (7.3–14.1)	0.4
WBC × 10^9/L	4.6 (2.2–9.4)	3.7 (1.5–14.3)	0.1
ANC × 10^9/L	2.6 (0.8–6.9)	2.4 (1.0–10.0)	0.9
ALC × 10^9/L	1.33 (0.51–4.61)	0.39 (0.15–3.94)	<0.0001
AMC × 10^9/L	0.43 (0.15–1.58)	0.63 (0.29–4.02)	<0.0001
Plts × 10^9/L	172 (121–373)	163 (177–334)	0.2

Abbreviations: ALC: absolute lymphocyte count; ANC: absolute neutrophil count; AMC: absolute monocyte count; CR: complete remission; IPS: international prognostic score; PR: partial response; Plts: platelets; and WBC: white blood cell count.