Innovative Analyses Support a Role for DNA Damage and an Aberrant Cell Cycle in Myelodysplastic Syndrome Pathogenesis
Multiparametric flow cytometry analysis of representative MDS bone marrow. Multiparametric flow cytometry analysis of a representative MDS case using the same analytical scheme and color coding as described in Figure 1. G-M progenitors (green) contain an accumulation of cells in G2 with diminished mitosis (M) compared to G-M progenitors in the control marrow (Figure 1). In this case erythroid precursors (red) and CD34+ stem cells (blue) exhibit relatively normal cell cycle parameters (DNA content, mitotic cells) versus the control sample (Figure 1).
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