Bioactive glasses (BGs), first introduced in 1969, have widespread clinical applications in maxillofacial therapy, orthopedic repair, and wound repair, and can function as carriers for bio-active molecules and therapeutic drugs. As a bioinorganic material, BGs have great osteoinductivity and osteoconductivity and can activate gene expression and stimulate bone regeneration. BGs have great biodegradability and biocompatibility and therefore offer excellent potential for bone tissue regeneration scaffolds and substitute materials.

In both in vivo and in vitro environments, BGs can guide the formation of hydroxyapatite on the biological surface. However, the poor mechanical properties, the sole functional component, and the low degradability limit the clinical application of BGs in repairing defects in non-loading areas and in other aspects. The optimization and regulation of these aspects are essential. As a bioinorganic material in bone regeneration, the development of BGs, regulation of their properties, such as synthesis, modification, and control of related cellular reactions, have great research potential. Recently, there has been extensive research to assess antibacterial effects, mineralization properties, and crystallization mechanisms and the biological behavior of composite materials has been evaluated based on BGs both in vivo and in vitro. The presence of different factors may influence the biological behavior of the composite materials, including osteoblast activity and stimulation of angiogenesis. Furthermore, composite scaffolds containing other biomaterials and BGs have also been developed. The investigation of novel hybrid materials with adjustable mechanical properties and degradability has also been a focus of recent research.

This Special Issue aims to publish the latest original research and review articles on the research, development, and innovation of bioactive glasses for biomedical applications. We aim to address the current limitations in order to optimize BGs for medical applications. We invite submissions from researchers in biomaterials and clinical therapy. We also welcome research focusing on other bioinorganic materials.

Potential topics include but are not limited to the following:

• In vivo and in vitro studies of BGs
• Novel applications of BGs
• Modification and characterization of BGs
• Assessment of BGs-based composites materials
• Simulation, modeling, and finite element analysis of BGs for bio-medical applications