Research Article

Synthesis and Optimization of Deesterified Acacia-Alginate Nanohydrogel for Amethopterin Delivery

Table 3

Mean particle size responses with respect to process parameters and their levels.

LevelDEA solution concentration (w/v)Alginate molecular weight (MW)ATN/DEA ratio (w/w %)

1193.8324.9250.7
2318.6321.4281.6
3298.2256.9374.2
4388.8296.1292.9
Delta195.068.0123.6
Rank132