The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications

Table 4

ZnO NPs with anti-inflammatory activity.

Type of NPs	Size	Effects
ZnO-functionalized textile fibers	—	A rapid improvement of AD severity, pruritus, and subjective sleep quality when AD patients wore the ZnO textiles overnight on 3 consecutive days [114]
ZnO NPs	—	ZnO NPs exerted higher anti-inflammatory properties by decreasing drastically on proinflammatory cytokines in the mouse model of AD [115]
ZnO NPs	Spherical: 33.03–73.48 nm	ZnO NPs relieved inflammation and displayed a dose-dependent effect in the suppression of related protein expressions [30]
ZnO NPs	Spherical: 96–115 nm; hexagonal: 57 ± 0.3 nm	ZnO NPs exhibited excellent anti-inflammatory activity with 66.78 μg/mL IC50 value [26]
ZnO incorporated into TiO2 nanotubes (TNTs/ZnO)	—	TNTs/ZnO had a significant inhibitory effect on the proliferation and adhesion of macrophages [117]
ZnO NPs and Ag NPs	—	ZnO NPs had a higher potential for anti-inflammatory (79%) in comparison with Ag NPs (69.1%) [116]
ZnO NPs	69.4 ± 13.0 nm	The anti-inflammatory abilities of ZnO NPs to suppress proinflammatory cytokines IL-1β and TNF-α and myeloperoxidase (MPO) in the colitic mice and activate Nrf2 signaling [118]
ZnO NPs	—	Dietary supplementation with ZnO NPs was effective in inhibiting mRNA expression of inflammatory cytokines (IFN-γ, IL-1β, TNF-α, and NF-κB) in the ileum in weaned piglets [119]