Potentiometric and Blood Plasma Simulation Studies of Nickel(II) Complexes of Poly(amino)amido Pentadentate Ligands: Computer Aided Metal-Based Drug Design
Table 1
Formation constants () for Ni(II) complexes of L1, L2, and L3, , mol dm−3 (NaCl), and C.
Ligand
Metal
()
L1
H+
0
1
1
9.20 (0.01)
0.01
0.01
0
1
2
17.88 (0.01)
0
1
3
19.91 (0.03)
Ni(II)
Model 1
1
1
1
13.88 (0.01)
0.02
0.01
1
1
−1
−1.82 (0.02)
1
1
−2
−10.92 (0.02)
Model 2
1
1
0
6.08 (0.04)
0.04
0.02
1
1
−1
−2.00 (0.04)
1
1
−2
−10.94 (0.04)
L2
H+
0
1
1
8.64 (0.01)
0.01
0.01
0
1
2
16.72 (0.01)
0
1
3
18.46 (0.06)
Ni(II)
Model 1
1
1
1
11.22 (0.07)
0.02
0.01
1
1
−1
−4.99 (0.02)
1
1
−2
−13.94 (0.01)
Model 2
1
1
0
2.17 (0.38)
0.02
0.01
1
1
−1
−5.05 (0.02)
1
1
−2
−13.99 (0.01)
L3
H+
0
1
1
4.62 (0.01)
0.01
0.01
0
1
2
8.13 (0.01)
0
1
3
10.11 (0.05)
Ni(II)
1
1
1
7.70 (0.08)
0.03
0.02
1
1
0
3.69 (0.04)
1
1
−1
−2.65 (0.04)
1
1
−2
−9.84 (0.03)
denotes standard deviation in , and and are the Hamiltonian -factor and its limit. The general formula of a complex is .