Research Article
Antioxidant Enzyme Inhibitor Role of Phosphine Metal Complexes in Lung and Leukemia Cell Lines
Table 1
Specific activities of TrxR, GPx, and Cat enzymes in the given period, after incubation of A549 and K562 cells, with IC50 values of metal complexes.
|
A549 |
K562 | | | U/mg protein | | | U/mg protein |
| TrxR | Control C1 C2 C3 | 0.5080ax ± (0.00458)y 0.4740a ± (0.00529) 0.2600b ± (0.01114) 0.2960b ± (0.00557) | TrxR | Control C1 C2 C3 | 1.0640a ± (0.00529) 0.5867d ± (0.01155) 0.7200b ± (0.05568) 0.6070c ± (0.02000) |
| GPx | Control C1 C2 C3 | 0.1520a ± (0.00265) 0.0680c ± (0.00854) 0.1067b ± (0.00351) 0.0460d ± (0.00361) | GPx | Control C1 C2 C3 | 0.2367a ± (0.00577) 0.0200b ± (0.00000) 0.0000b ± (0.00000) 0.0000b ± (0.00000) |
| Cat | Control C1 C2 C3 | 854.73a ± (0.00008) 281.68c ± (0.00005) 530.41b ± (0.00002) 252.36d ± (0.00002) | Cat | Control C1 C2 C3 | 354.9300a ± (3.27432) 131.8900b ± (1.47401) 121.9100c ± (1.80602) 108.8163d ± (2.78970) |
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Among groups mean value ( = 3), standard deviation, Significant differences (1: ≤ 0.05; 2: ≤ 0.01; 3: ≤ 0.001) in a row.
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