Detection of HIV-1 and Human Proteins in Urinary Extracellular Vesicles from HIV+ Patients

Table 6

Functional enrichment analysis of HIV+ EV proteins.

	Genes in the dataset	Genes in the Bkg. database	Percentage of genes	Fold enrichment	Corrected value (BH FDR)
Molecular function
Protein serine/threonine kinase activity	272	5,602	30	1.18	1.04^−08
Catalytic activity	456	827	4.9	1.1	1.12^−05
GTPase activator activity	131	836	4.7	1.2	8.14^−05
Guanyl-nucleoside exchange factor activity	105	614	3.6	1.2	8.54^−05
Cell adhesion molecule activity	307	531	3.3	1.1	0.0001
Biological process
Regulation of nucleobase, nucleoside, and nucleic acid	2,236	4,658	24.8	1.05	3.24^−05
Biological pathway
Integrin cell surface interactions	69	1,366	23.3	1.2	0.03