Phage-Displayed Peptides Selected to Bind Envelope Glycoprotein Show Antiviral Activity against Dengue Virus Serotype 2

Figure 6

Probable binding modes of active peptides on their targets, as explored by molecular docking simulation. (a) Most favorable pose of peptide ELLASPW on the DENV2 envelope. Inset shows more details of putative binding site. (b) Most favorable poses of peptides STSFWIT and SYQSHYY on domain III. Peptide STSFWIT occupies the upper binding site of the molecule in this diagram. Proteins are depicted in their hydrophobicity surfaces, while peptides are in stick model. (c) Interaction diagram for ELLASPW-envelope. (d) Interaction diagram for STSFWIT-domain III. (e) Interaction diagram for SYQSHYY-domain III. Interaction diagrams were done in LigPlot+. Intermolecular hydrogen bonds are indicated by green dashed lines, while hydrophobic interactions are represented by arcs and radiating spokes. Pose figures were prepared using UCSF Chimera.

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