Histoprotective Effect of Essential Oil from Citrus aurantifolia in Testosterone-Induced Benign Prostatic Hyperplasia Rat

Figure 7

Photomicrographs of testis showing spermatogenic series in seminiferous tubules: (a) sham; (b) model, TE (10 mg/kg)/olive oil injection (i.m.); (c) finasteride (positive control), TE (10 mg/kg)/olive oil injection (i.m.) + finasteride administration (15 mg/kg, p.o.); (d) small dose, TE (10 mg/kg)/olive oil injection (i.m.) + LEO (30 mg/kg); (e) medium dose, TE (10 mg/kg)/olive oil injection (i.m.) + LEO (100 mg/kg); (f) high dose, TE (10 mg/kg)/olive oil injection (i.m.) + LEO (300 mg/kg). Red arrow represents spermatozoon in adluminal compartment, black arrows represent germinal epithelium. Model group had less compact germinal epithelium, severe pyknosis in the germinal epithelium (black arrow) and few or no spermatozoa in the adluminal compartment of the seminiferous tubules as well as eosinophilic secretion in the interstitial space. Lime essential oil treatment group had dose dependent decrease in these features.

(a)

(b)

(c)

(d)

(e)

(f)