Liver Enzymes Abnormalities among Highly Active Antiretroviral Therapy Experienced and HAART Naïve HIV-1 Infected Patients at Debre Tabor Hospital, North West Ethiopia: A Comparative Cross-Sectional Study
Table 3
Multiple logistic regression analysis of factors for ALT and/or AST enzyme abnormalities in HIV-1 infected patients at Debre Tabor Hospital, 2013.
Variables
Liver enzyme
COR (95% CI)
AOR (95% CI)
Normal (%)
Abnormal (%)
Education level
Illiterate
130 (42.8)
7 (29.2)
0.59 (0.17–2.12)
0.52 (0.14–1.97)
Elementary
82 (27.0)
11 (45.8)
1.48 (0.44–4.91)
1.54 (0.44–5.41)
High school
48 (15.8)
2 (8.3)
0.46 (0.08–2.63)
0.34 (0.06–2.078)
College & above
44 (14.5)
4 (16.7)
1
1
Marital status
Single
53 (17.4)
9 (37.5)
1
—
Married
136 (44.7)
10 (41.7)
0.43 (0.17–1.13)
—
Divorced
66 (21.7)
2 (8.3)
0.18 (0.04–0.86)
—
Widowed
49 (16.1)
3 (12.5)
0.36 (0.09–1.41)
—
Sex
Male
100 (36.5)
27 (50.0)
1.74 (0.98–3.13)
1.83 (1.001–3.33)
Female
174 (63.5)
27 (50.0)
1
1
CD4 count/cells/mm3
<200
73 (26.6)
24 (44.4)
2.10 (1.04–4.22)
2.16 (1.06–4.39)
200–350
99 (36.1)
14 (25.9)
0.90 (0.42–1.95)
0.91 (0.42–1.98)
>350
102 (37.2)
16 (29.6)
1
1
OIs
No
266 (87.5)
18 (75.0)
1
1
Yes
38 (12.5)
6 (25.0)
2.33 (0.87–6.25)
2.91 (1.04–8.19)
HAART status
No
154 (50.7)
10 (41.7)
1
—
Yes
150 (49.3)
14 (58.3)
1.44 (0.62–3.34)
—
HBV or HCV
Positive
17 (5.6)
5 (20.8)
4.44 (1.48–13.35)
6.02 (1.87–19.39)
Negative
287 (94.4)
19 (79.2)
1
1
Significantly associated; OI: opportunistic infection; HBV: hepatitis B virus; HCV: hepatitis C virus; HAART: highly active antiretroviral therapy; AOR: adjusted odds ratio; COR: crude odds ratio; CI: confidence interval.
