Review Article
Monitoring Antiretroviral Therapy in HIV-Infected Children in Resource-Limited Countries: A Tale of Two Epidemics
Table 2
Immunologic and virologic outcomes of antiretroviral therapy in HIV-infected children in resource-limited countries.
| Study | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | Average of all studies |
| Number of children | 2928 | 67 | 151 | 29 | 107 | 212 | 285 | 274 | 67 | 250 | 78 | — | Country [ref]* | Zambia [24] | India [57] | South Africa [25] | Kenya [54] | Thailand [55] | Cambodia [23] | Haiti [22] | Thailand [56] | Kenya [39] | Uganda [61] | Cote d’Ivoire [62] | — | Median age (years) | 6.75 | 6.28 | 5.3 | 8.5 | 7.7 | 6 | 6.3 | 7 | 4.4 | 9.2 | 6.5 | 6.7 | WHO clinical staging III or IV (%) | 72.4 | 49.3 | 70.2 | 62.1 | 72 | 64.5 | 98 | 65 | 82 | 89 | na | 72.5 | Median CD4 count at baseline (cells/mm3) | 284 | 225 | na | 182.3 | 72 | 100 | 608 | na | 288 | 272 | na | 253.9 | CD4 gain at 6 months | 280 | 478 | na | 203 | 226 | na | na | na | 210 | na | na | 279.4 | CD4 gain at 12 months | 351 | 516 | na | 334 | 332 | 490 | na | na | na | na | na | 404.6 | CD4 gain at 18¶ or 24 months | 427¶ | 493¶ | na | na | 532 | na | na | na | na | na | na | 460¶ | Median CD4% at baseline | 12.9 | 12 | 7.4 | na | 3 | 6 | 12 | 5 | 5.8 | 8.6 | 7.5 | 8.02 | CD4% gain at 6 months | 10.8 | 8 | 10.2 | na | 12 | na | na | 7 | 9.4 | na | 4.6 | 8.86 | CD4% gain at 12 months | 14.1 | 11 | 16.2 | na | 17 | 17 | 10.3 | na | na | na | 11.1 | 13.8 | CD4% gain at 18¶ or 24 months | 15.1¶ | 13¶ | na | na | 21 | na | na | 18 | na | na | 16 | 19.5 | Median viral load (VL) at baseline (Log) | na | na | na | 5.11 | 5.4 | na | 5.3 | na | 6.1 | 5.3 | 5.37 | 5.43 | Proportion with undetectable VL at 6 months (%) | na | na | 84 | ~50 | 53 | na | na | na | 67 | na | 52.1 | 61.2 | Proportion with undetectable VL at 12 months (%) | na | na | 80.3 | na | 69 | 81 | 56 | na | na | 74 | 49.3 | 68.26 | Proportion with undetectable VL at 18 months (%) | na | na | na | na | 76 | na | na | na | na | na | 47.5 | 61.75 | Frequency of CD4 determination (months) | 6 | 3–6 | 6 | 3 | 6 | 6 | 6 | na | 3–6 | 3–6 | 6 | — |
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*Reference to papers from which figures were extracted. ¶Values available at 18 months. na: not available.
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