Crystal Structures of the Putative Isocitrate Dehydrogenase from Sulfolobus tokodaii Strain 7 in the Apo and NADP⁺-Bound Forms

Figure 5

Structural comparisons of the binding site of the 2-phosphate group of NADP⁺ between ST2166, ApIDH, and EcIDH. (a–d) View of the binding site of ST2166 (a), ApIDH in the open form (b), ApIDH in the closed form (c), and EcIDH in the closed form (d), respectively. Polypeptide chains are drawn in a ribbon model. NADP⁺, isocitrate, and residues are shown in a stick model. Oxygen, nitrogen, and sulfur atoms are shown in red, blue, and orange, respectively. Red dotted lines indicate hydrogen bonds.

(a)

(b)

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(d)