Crystal Structures of the Putative Isocitrate Dehydrogenase from Sulfolobus tokodaii Strain 7 in the Apo and NADP⁺-Bound Forms

Figure 4

View around the binding site of NADP⁺. (a) View around the active site cleft. NADP⁺ is drawn in a sphere model. NADP/putative isocitrate bound residues are shown in a stick model. Thr101 is colored in pink. Polypeptide chains are drawn in a cylinder model. (b) Omit maps of NADP⁺. Maps are contoured at 1.6 σ superimposed with the final model. (c) View of the NADP⁺-binding site. Residues in the apo and holo forms are colored in white and yellow, respectively, and superimposed. Oxygen, nitrogen, and sulfur atoms are shown in red, blue, and orange, respectively. Dotted lines indicate hydrogen bonds.

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