Nuclear-Targeting Delivery of CRISPRa System for Upregulation of β-Defensin against Virus Infection by Dexamethasone and Phenylalanine Dual-Modified Dendrimer

<div>Cell viability of dendrimers to (a) human kidney 293T cells, (b) mouse neuroblastoma N2a cells, (c) and human lung adenocarcinoma A549 cells. Incubation time: 48 h. Dose: 55.6 μM. Complexes were prepared at N/P of 6 for G4 (Phe)25%/EGFP, N/P of 8 for G4 (Phe)50%/EGFP, and N/P of 8 for G4 (Phe)50%-DET/EGFP, respectively. The concentrations of EGFP plasmid were 1, 2, and 3 μg/mL, respectively.</div>

Advances in Polymer Technology

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Figure 4: Nuclear-Targeting Delivery of CRISPRa System for Upregulation of β-Defensin against Virus Infection by Dexamethasone and Phenylalanine Dual-Modified Dendrimer

Figure 4 | Nuclear-Targeting Delivery of CRISPRa System for Upregulation of β-Defensin against Virus Infection by Dexamethasone and Phenylalanine Dual-Modified Dendrimer 