Brucine Entrapped Titanium Oxide Nanoparticle for Anticancer Treatment: An In Vitro Study

Figure 2

(a) Demonstration of the cytotoxic effects of Brucine entrapped TiO₂ NPs in a dose-dependent manner (2–500 µg/ml). The IC₅₀ of Brucine entrapped TiO₂ NPs on Hela cell lines was noticed at 30 µg/ml concentration. (b) Representation of the percentage of cell viability. Trypan blue exclusion assay was used to examine the effect of Brucine entrapped TiO₂ NPs on Hela cell lines. (c) Representation of the inhibitory action of Brucine entrapped TiO₂ NPs was assessed by morphological alterations in Hela cell lines. The treated cells showed cell shrinkage, rupturing of cells, and cell rounding when compared to untreated cells. The distinct morphology was observed in control cells.

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