Solubility Enhancement of a Poorly Water-Soluble Drug Using Hydrotropy and Mixed Hydrotropy-Based Solid Dispersion Techniques
Table 5
The results of equilibrium solubility of rosuvastatin calcium in a mixture of three hydrotropic agents of different ratios with a total concentration of 40%.
Combination
Total concentration (%W/V)
Individual concentration (%W/V)
Solubility, mg/ml
Solubility enhancement ratio
SS : SB : M
40
13.333
73.81 ± 1.49
172.722
SS : SB : C
40
13.333
47.86 ± 1.43
112.005
SS : SB : U
40
13.333
191.94 ± 38.63
449.137
SS : SB : U
40
20 : 10 : 10
100.6 ± 12.7
235.414
SS : SB : U
40
20 : 15 : 05
128.77 ± 4.02
301.328
SS : SB : U
40
20 : 05 : 15
89.87 ± 5.18
210.314
SS : SB : U
40
10 : 15 : 15
85.58 ± 1.74
200.265
Each hydrotropic agent 13.333. The data are presented as the mean ± SD (n = 3).
