Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats

Figure 3

Representative histopathology slides (×20) of rat livers from control (untreated) and PAR treated rats and their respective pathology reports. (a) (No PAR): section of rat liver from the untreated group: “No pathology appears to be present in the control (untreated) animals”; (b) (PAR × 2 days): PAR for 2 days. “moderate granular vacuolar degeneration and cell swelling, and minimal cytonecrosis, loss of cell boundaries, minimal mitosis, and minimal centrilobular zonal necrosis”. (c) (PAR × 7 days): PAR for 7 days: “mild degeneration and minimal cytonecrosis”. (d) (PAR × 14 days): PAR for 14 days. “moderate granular vacuolar degeneration and cell swelling, and minimal cytonecrosis loss of cell boundaries, minimal mitosis, and minimal hepatocyte mitosis”. (e) (PAR × 28 days): PAR for 28 days: “Hepatic cords with minimal vacuolar degenerative changes (×20)”; (f) (PAR × 42 days): PAR for 42 days: “Periportal hepatocytes, minimal degeneration visible (×20)”.

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