Research Article
Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties
Table 1
Effects of naproxen and its metal chelates on acetic acid-induced writhing response in mice.
| Group | Dose | Number of writhes (mean ± SEM) | % inhibition of writhing |
| Control | 10 mL/kg | 14.2 ± 1.07 | — | Standard | 25 mg/kg | 6.4 ± 0.68 | 54.93 | Naproxen-copper complex | 25 mg/kg | 5.8 ± 0.86 | 59.15 | Naproxen-copper complex | 50 mg/kg | 3.8 ± 0.58 | 73.24 | Naproxen-cobalt complex | 25 mg/kg | 5.6 ± 0.68 | 60.56 | Naproxen-cobalt complex | 50 mg/kg | 3.6 ± 0.51 | 74.65 | Naproxen-iron complex | 25 mg/kg | 7.4 ± 0.40 | 47.89 | Naproxen-iron complex | 50 mg/kg | 5.6 ± 0.51 | 60.56 | Naproxen-silver complex | 25 mg/kg | 6.6 ± 0.93 | 53.52 | Naproxen-silver complex | 50 mg/kg | 4.2 ± 0.73 | 70.42 | Naproxen-zinc complex | 25 mg/kg | 6.0 ± 0.31 | 57.75 | Naproxen-zinc complex | 50 mg/kg | 4.6 ± 0.68 | 67.60 |
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Each value represents the mean ± SEM, . was considered significant compared with control.
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